The first notable intervention was done by the CIA and the British to oust the democratically elected leader Muhammad Musaddique who was had been assassinated in 1953.
The intervention resulted in installing the dictator puppet Shah Mohammed Riza Bahlavi. The Shah cracked down on religious groups, promoted neoliberal values and become an important ally to the imperialists.
A tension between the United States and Iran sparked after ousting the Shah regime by the Islamic revolution in 1979. The US intervention and its bolstering the Shah regime was recognized by the Iranians which led to the hostage crisis of the US embassy in Tehran.
Shortly after the crisis has ended, the US backed the Iraqi war against the newly formed Iranian government which lasted for 8 years with hundreds of thousands of casualties from both sides.
This culminated on July 3, 1988, when a US warship attacked an Iranian civilian jetliner which it claims to have mistaken for an F14 fighter plane. The attack killed all 290 passengers aboard Iran Air Flight 655. Admiral Crowe, the Joint Chiefs chairman at the time, said the US “deeply regretted” the killings.
Iran became an active target of the neocons after the end of the war, with an ever escalating tensions, the US targeted Iran with an economic warfare with sanctions under the alleged threat of developing nuclear weapons.